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Comparison of the ultra-low-dose Veo algorithm with the gold standard filtered back projection for detecting pulmonary asbestos-related conditions: a clinical observational study

Identifieur interne : 003B07 ( Main/Exploration ); précédent : 003B06; suivant : 003B08

Comparison of the ultra-low-dose Veo algorithm with the gold standard filtered back projection for detecting pulmonary asbestos-related conditions: a clinical observational study

Auteurs : Marielle Tekath [France] ; Frédéric Dutheil [France, Australie] ; Romain Bellini [France] ; Antoine Roche [France] ; Bruno Pereira [France] ; Geraldine Naughton [Australie] ; Alain Chamoux [France] ; Jean-Luc Michel [France]

Source :

RBID : PMC:4039784

Descripteurs français

English descriptors

Abstract

Objectives

Radiation delivered during CT is a major concern, especially for individuals undergoing repeated screening. We aimed to compare a new ultra-low-dose algorithm called Veo with the gold standard filtered back projection (FBP) for detecting pulmonary asbestos-related conditions.

Setting

University Hospital CHU G. Montpied, Clermont-Ferrand, France

Participants

Asbestos-exposed workers were recruited following referral to screening for asbestos-related conditions. Two acquisitions were performed on a 64-slice CT: the gold standard FBP followed by Veo reconstruction.

Outcome measures

Two radiologists independently assessed asbestos-related abnormalities, pulmonary nodules, radiation doses and image quality (noise).

Results

We included 27 asbestos-exposed workers (63.3±6.5 years with 11.9±9.7 years of asbestos exposure). We observed 297 pleural plaques in 20 participants (74%). All patients (100%) had pulmonary nodules, totalling 167 nodules. Detection rates did not differ for pleural plaques (Veo 87% vs FBP 97%, NS), pleural thickening (100% for both) and pulmonary nodules (80% for both). Interstitial abnormalities were depicted less frequently with Veo than FBP. False negative and false positive did not exceed 2.7%. Compared with FBP, Veo decreased the radiation dose up to 87% (Veo 0.23±0.07 vs FBP 1.83±0.88 mSv, p<0.001). The objective image noise also decreased with Veo as much as 23% and signal-to-noise ratio increased up to 33%.

Conclusions

A low-dose CT with Veo reconstruction substantially reduced radiation. Veo compared favourably with FBP in detecting pleural plaques, pleural thickening and pulmonary nodules. These results should be confirmed on a larger sample size before the use of Veo in clinical routine practice in asbestos-related conditions, especially regarding the low prevalence of interstitial abnormalities in this study.

Trial registration number

NCT01955018.


Url:
DOI: 10.1136/bmjopen-2014-004980
PubMed: 24879827
PubMed Central: 4039784


Affiliations:


Links toward previous steps (curation, corpus...)


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<sec>
<title>Objectives</title>
<p>Radiation delivered during CT is a major concern, especially for individuals undergoing repeated screening. We aimed to compare a new ultra-low-dose algorithm called
<italic>Veo</italic>
with the gold standard filtered back projection (FBP) for detecting pulmonary asbestos-related conditions.</p>
</sec>
<sec>
<title>Setting</title>
<p>University Hospital CHU G. Montpied, Clermont-Ferrand, France</p>
</sec>
<sec>
<title>Participants</title>
<p>Asbestos-exposed workers were recruited following referral to screening for asbestos-related conditions. Two acquisitions were performed on a 64-slice CT: the gold standard FBP followed by
<italic>Veo</italic>
reconstruction.</p>
</sec>
<sec>
<title>Outcome measures</title>
<p>Two radiologists independently assessed asbestos-related abnormalities, pulmonary nodules, radiation doses and image quality (noise).</p>
</sec>
<sec>
<title>Results</title>
<p>We included 27 asbestos-exposed workers (63.3±6.5 years with 11.9±9.7 years of asbestos exposure). We observed 297 pleural plaques in 20 participants (74%). All patients (100%) had pulmonary nodules, totalling 167 nodules. Detection rates did not differ for pleural plaques (
<italic>Veo</italic>
87% vs FBP 97%, NS), pleural thickening (100% for both) and pulmonary nodules (80% for both). Interstitial abnormalities were depicted less frequently with
<italic>Veo</italic>
than FBP. False negative and false positive did not exceed 2.7%. Compared with FBP,
<italic>Veo</italic>
decreased the radiation dose up to 87% (
<italic>Veo</italic>
0.23±0.07 vs FBP 1.83±0.88 mSv, p<0.001). The objective image noise also decreased with
<italic>Veo</italic>
as much as 23% and signal-to-noise ratio increased up to 33%.</p>
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<sec>
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<p>A low-dose CT with
<italic>Veo</italic>
reconstruction substantially reduced radiation.
<italic>Veo</italic>
compared favourably with FBP in detecting pleural plaques, pleural thickening and pulmonary nodules. These results should be confirmed on a larger sample size before the use of
<italic>Veo</italic>
in clinical routine practice in asbestos-related conditions, especially regarding the low prevalence of interstitial abnormalities in this study.</p>
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<sec>
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